Recombination in Vertebrate Cells Double-Strand Breaks by Homologous Radiation- and Enzyme-Induced DNA Fanconi Anemia FANCG Protein in Mitigating
نویسندگان
چکیده
10.1128/MCB.23.15.5421-5430.2003. 2003, 23(15):5421. DOI: Mol. Cell. Biol. Minoru Takata Mitsune Tanimoto, Mine Harada, Larry H. Thompson and Hiroshi Arakawa, Jane E. Lamerdin, Jean-Marie Buerstedde, Kazuhiko Yamamoto, Masamichi Ishiai, Nobuko Matsushita, Recombination in Vertebrate Cells Double-Strand Breaks by Homologous Radiationand Enzyme-Induced DNA Fanconi Anemia FANCG Protein in Mitigating
منابع مشابه
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.
Fanconi anemia (FA) is a recessive disorder characterized by congenital abnormalities, progressive bone-marrow failure, and cancer susceptibility. Cells from FA patients are hypersensitive to agents that produce DNA crosslinks and, after treatment with these agents, have pronounced chromosome breakage and other cytogenetic abnormalities. Eight FANC genes have been cloned, and the encoded protei...
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DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
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Recombination repair plays an important role in the processing of DNA double-strand breaks (DSB) and DNA cross-links, and has been suggested to be mediated by the activation of the Fanconi anemia (FA)/BRCA pathway. Unlike DNA damage generated by ionizing radiation or DNA cross-linking, UV light-induced DNA damage is not commonly thought to require recombination for processing, as UV light does ...
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